“The two most common questions that patients ask me are, ‘Will I become dependent on the medications?’ and ‘Will I gain weight?’” says Everyday Health contributor Sanjay Gupta, M.D. It’s a serious concern for people considering taking any kind of psychiatric medicine, and a sensitive subject among patients who are currently on meds. “A rapidly expanding waistline is one of the major reasons why patients prematurely discontinue an otherwise effective treatment, fall back into depression, and experience a poor outcomes,” says Gupta.