http://goo.gl/QS3p8q
These findings may be relevant to the high rates of smoking in schizophrenia.
"The data seem to suggest that smoking might produce some clinical benefits for some patients by increasing the availability of receptor targets for nicotine in the brain," commented Dr. John Krystal, Editor ofBiological Psychiatry. "This finding adds to evidence that brain nicotine-related signaling might play a role for new medications developed to treat schizophrenia."