http://goo.gl/2ufgaJ
More than 80 percent of people with depression in the general population aren't eligible for clinical trials of antidepressantdrugs, according to a study in the Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.
At least five patients would need to be screened to enroll just one patient meeting the typical inclusion and exclusion criteria for antidepressant registration trials (ARTs), suggests the new research by Drs. Sheldon Preskorn and Matthew Macaluso of University of Kansas School of Medicine-Wichita and Dr. Madhukar Trivedi of Southwestern Medical School, Dallas. The study highlights some major differences between patients with depression seen in everyday clinical practice and those enrolled in ARTs--the studies of antidepressants that lead to FDA drug approval.