Antidepressants shown to worsen depression in patients with rapid-cycling bipolar disorder

http://goo.gl/HQk8EG

In the trial, the authors tracked patients with BD following an acute depressive episode. They found that rapid-cycling patients who continued antidepressants following initial treatment for the episode experienced three times the number of depressive episodes the following year as those who discontinued use of antidepressants. RC patients who continued antidepressants were episode-free 52 percent of the time, while RC patients who discontinued antidepressants were episode-free 64 percent of the time.