Fear of math can activate regions of the brain linked with the experience of physical pain and visceral threat detection, according to research published Oct 31 by Ian Lyons and colleagues at the University of Chicago in the open access journal PLOS ONE.The researchers found that in individuals who experience high levels of anxiety when facing math tasks, the anticipation of math increases activity in regions of the brain associated with the physical sensation of pain. The higher an individual's math anxiety, the more such neural activity was increased.