The agent promoting acute inflammation (LPS) in mice induced, as expected, sickness behaviour with lower locomotor activity within the first 6 hours compared to the control group. Acute inflammation also induced anxiety 24 hours later, paralleled by significant increases in the brain, in pro-inflammatory cytokines and in a serotonin receptor. These receptors play a key role in the brain-gut axis, brain development and neuro-psychiatric disorders. Bimuno reduced post-inflammation anxiety 24 hours post-LPS injection while the brain inflammation observed in the control group was normalised in the Bimuno group. The effects of Bimuno were mediated by an action on the immune system and brain chemistry, via a reduction in the key pro-inflammatory cytokine IL-1 beta release and by an impact on the serotonin receptor 5HT2A.
New biome research every day, it seems.....
http://goo.gl/dz4y2QIt is the first study to demonstrate that a prebiotic can have a modulatory role in neuro-immuno processes as well as reversing anxiety induced by inflammation. It also shows that the beneficial effects of Bimuno on brain health and emotions are also exerted via a combination of the immune system and a key receptor in the brain, a serotonin receptor. This provides further evidence of the link between the immune and central nervous systems (CNS) in the development of anxiety and other stress related disorders. Previously, probiotics have demonstrated positive effects on the CNS, behaviour and the immune system, but these effects had never been demonstrated with a prebiotic within a single study.