(T)he review, to be published in Neuropsychiatry, a bimonthly peer-reviewed journal from Future Medicine, reinforces the 'traumagenic neurodevelopmental' model of psychosis, which suggests that those differences can be caused by adverse life events, especially those occurring in early childhood. For example, the maladaptive stress regulation mechanisms in the brain that are related to over-sensitivity to stressors are also found in the brains of traumatised young children.