The team presented the research at the American Physiological Society's annual meeting during the Experimental Biology 2017 conference, held in Chicago, IL.
Essential oils are naturally produced by plants and can be used for therapeutic purposes. The aromatic compounds of orange essential oil are usually extracted from the peel of the orange. Essential oils can be inhaled, applied to the skin, or ingested in foods or beverages.
The researchers found that the mice exposed to orange essential oil were significantly less likely to exhibit freezing behavior and stopped freezing altogether earlier than the mice that received water and fear conditioning. Moreover, the mice exposed to orange essential oil experienced a significant decrease in the immune cells linked to the "biochemical pathways" associated with PTSD.
The mechanism behind the differences in behavior between the two groups could be explained by the variations found in gene expression in their brains.
"Relative to pharmaceuticals, essential oils are much more economical and do not have adverse side effects. The orange essential plant oil showed a significant effect on the behavioral response in our study mice. This is promising because it shows that passively inhaling this essential oil could potentially assuage PTSD symptoms in humans."
Cassandra Moshfegh