Recurrent major depressive disorder and use of antidepressants associated with lower bone density

http://goo.gl/6SLvh7

Antidepressant use was associated with lower BMD only in lower-weight men and varied across the bone sites. For example, the use of antidepressants was associated with reduced bone density in the hip in men weighing less than 110 kilograms. In the forearm, however, the association of anti-depressants with reduced bone density was not observed in men until their body weight was under 75 kilograms.

According to the study, recurrent major depression may increase the risk of osteoporosis in men. Furthermore, the use of antidepressants should be taken into account as a potential risk factor of osteoporosis especially in men with a low body weight.