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In this Virtual Forum, experts Roger McIntyre, MD, FRCPC, Professor of Psychiatry & Pharmacology at the University of Toronto, Head of the Mood Disorders Psychopharmacology Unit University Health Network, and Executive Director of the Brain & Cognition Discovery Foundation; and David Scheiderer, MD, MBA, DFAPA, Director of Education at Integrative Psychiatry, Inc reviewed the association between dysfunction of gut microbiota-brain axis and mental health disorders. They also discussed when, how, and in whom gut strategies for the evaluation and treatment of psychiatric illness may be appropriate.