That's 101.3 F, so it is a significant increase in body temperature. Don't try this at home.....
Heating the body to a state of mild hyperthermia created an antidepressant effect in people with major depressive disorder, according to a recent study (Janssen CW et al. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2016.1031 [published online May 12, 2016]). Raising participants’ core body temperature to 38.5°C significantly reduced depressive symptoms within 1 week of the intervention, and the effect was sustained for several weeks.