An indicator of how you might respond to ketamine for depression....
In the study, first author Dr. Wallace Duncan and his colleagues from the Experimental Therapeutics and Pathophysiology Branch at the National Institute of Mental Health in Bethesda, Maryland used wristwatch activity monitors to examine measures of circadian timekeeping systems, including the timing and levels of activity. The 51 patients included in the study had either major depressive disorder or bipolar disorder, and all of the patients had depressive symptoms that had not responded to previous treatment attempts.
Duncan and his colleagues showed that patients who responded to a single infusion of ketamine initially had more activity earlier in the day and lower activity later in the day than patients who did not respond to ketamine. “In other words, their daily activity clock was shifted forward,” said Dr. John Krystal, Editor of Biological Psychiatry.
Responders also had advance-shifted timing of their activity on the first day after the treatment, and increased overall activity levels on the third day, consistent with the notion that activity levels are part of the clinical response to ketamine.