Size of brain region is associated with response to PTSD treatment

A follow-up on yesterday's post on brain changes in PTSD....

http://goo.gl/nphsPw

A study has found that PTSD patients with a larger hippocampus--a region of the brain key to distinguishing between safety and threat--are more likely to respond to exposure-based therapy for posttraumatic stress disorder (PTSD).

The study, from researchers at Columbia University Medical Center (CUMC) and New York State Psychiatric Institute (NYSPI), was published online in Psychiatry Research: Neuroimaging on May 4, 2016.

Previous research has shown that having a smaller hippocampus is associated with increased risk of PTSD. In this study, the researchers examined the relationship between hippocampus volume, measured with MRI, and response to treatment in 50 participants with PTSD and 36 trauma-exposed healthy controls. The participants were evaluated at baseline and after 10 weeks, during which time the PTSD group had prolonged exposure therapy, a type of cognitive behavioral therapy that has been shown to help patients with PTSD discriminate between real and imagined trauma.

The study found that patients with PTSD who responded to treatment had greater hippocampal volume at the beginning of the study than non-responders to treatment.

The findings add to growing evidence that the hippocampus is key to distinguishing between cues that signal safety and those that signal threat.


How Does Post-Traumatic Stress Disorder Change the Brain?

http://goo.gl/WUXXbY

Child abuse. Rape. Sexual assault. Brutal physical attack. Being in a war and witnessing violence, bloodshed, and death from close quarters. Near death experiences. These are extremely traumatic events, and some victims bear the scars for life.

The physical scars heal, but some emotional wounds stop the lives of these people dead in their tracks. They are afraid to get close to people or form new relationships. Change terrifies them, and they remain forever hesitant to express their needs or give vent to their creative potential. It may not be always apparent, but post-traumatic stress disorder (PTSD) stifles the life force out of its victims. It is no use telling them to “get over” it because PTSD fundamentally changes the brain’s structure and alters its functionalities.

The most significant neurological impact of trauma is seen in the hippocampus. PTSD patients show a considerable reduction in the volume of the hippocampus. This region of the brain is responsible for memory functions. It helps an individual to record new memories and retrieve them later in response to specific and relevant environmental stimuli. The hippocampus also helps us distinguish between past and present memories.

PTSD patients with reduced hippocampal volumes lose the ability to discriminate between past and present experiences or interpret environmental contexts correctly. Their particular neural mechanisms trigger extreme stress responses when confronted with environmental situations that only remotely resemble something from their traumatic past. This is why a sexual assault victim is terrified of parking lots because she was once raped in a similar place. A war veteran still cannot watch violent movies because they remind him of his trench days; his hippocampus cannot minimize the interference of past memories.......

A new series of studies identifies an unknown psychological disorder: Maladaptive daydreaming

http://goo.gl/bDNcyN

A new psychological disorder has been identified in a series of recently published studies - Maladaptive Maydreaming (MD). Researchers from the University of Haifa, in Israel, Fordham University in New York City and University of Lausanne, Switzerland, have found that people with the disorder spend an average of 60% of their waking time in an imaginary world which they themselves have created, realizing that it is a fantasy, and without losing contact with the real world. "Daydreaming usually starts as a small fantasy that makes people feel good, but over time the process becomes addictive until it takes over their lives. At this stage the disorder is accompanied by feelings of shame and a sense of lack of fulfillment, but because till now the disorder has been unknown, when they come to receive treatment, therapists usually dismissed their complaints," explains Professor Eli Somer of the University of Haifa, one of the researchers and the first to identify the disorder.

Wandering of thoughts, fantasies and daydreams are part of the inner world of almost everyone, and they are depicted in popular culture - in literature and film, for example. However, until now science has not addressed the pathological aspects of this, otherwise normal mental activity. A series of new studies published recently in several leading journals in psychology and psychiatry shed light on a psychological disorder that was not known until now. The story begins in 2002, when Prof. Somer was treating adults who had been sexually abused as children. Somer identified six survivors who used to escape regularly into a world of the imagination, where they fantasized compensatory empowering stories in which they enjoyed traits and life experiences that were missing in their real lives. Professor Somer named the phenomenon "maladaptive daydreaming" (MD) but at the time did not continue his investigation of the phenomenon. This article was followed in 2011 by a study by Jayne Bigelsen and Cynthia Schupak of 90 people who complained of excessive daydreaming. Their study that showed that MD is also spread among many individuals who have not had adverse childhoods. In the wake of these two studies, Somer and Bigelsen began to receive communications from countless individuals from around the world who related to them how they had suffered from exactly the same phenomenon asking for their advise and help.


Bring them back

https://goo.gl/80Ufr0

Untold thousands of patients misdiagnosed as vegetative are actually aware. Theirs is the civil rights fight of our times.

I had just finished giving a talk about severe brain injury, and told the story of Terry Wallis, a man in Arkansas who’d had a car accident in 1984. He survived but was left in a vegetative state, and his doctors and family thought he would be unconscious forever. Then in 2003 he began to speak. Tentatively at first, he said ‘Mom’ and then ‘Pepsi’. It was a stunning development almost two decades after he was injured. Terry’s words became the stuff of international headlines, baffling commentators who thought that recovery from the vegetative state was impossible.

The trouble is that, most of the time, MCS patients are unable to demonstrate their awareness. One problem is that their level of arousal fluctuates. They cannot sustain attention and can drift in and out, making it difficult to engage with the outside world. And when they do interact, they are burdened by impairments in cognition.

This makes MCS more than a problem of communication, like the locked-in syndrome so poignantly captured by Jean-Dominique Bauby in The Diving Bell and the Butterfly (1997). Bauby, unlike the MCS patient, was cognitively intact. He had a communication disorder but was still able to write his memoir, blinking to create the words in a kind of personal Morse code.


Interventional policies & practices needed to prevent bullying & its harm

http://goo.gl/2gbdWp

Bullying is a serious public health problem, with significant short- and long-term psychological consequences for both the targets and perpetrators of such behavior, and requires a commitment to developing preventive and interventional policies and practices that could make a tangible difference in the lives of many children, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The programs that appear most effective are those that promote a positive school environment and combine social and emotional skill-building for all students, with targeted interventions for those at greatest risk for being involved in bullying. There is emerging research that widely used zero-tolerance policies -- those that impose automatic suspension or expulsion of students from school after one bullying incident -- are not effective at curbing bullying or making schools safer and should be discontinued. Instead, resources should be directed to evidence-based policies and programs for bullying prevention in the United States.



Study finds many patients abusing drugs and alcohol 
are self-medicating chronic pain

Duh! of the week.....

http://goo.gl/wjj1Jk

With opioid addiction and prescription drug abuse considered one of the biggest public health threats of our time in the U.S., many are asking why so many Americans are struggling with addiction to illegal drugs and prescription medications. New research suggests that chronic pain may be part of the answer.

In a study that appears in the Journal of General Internal Medicine, researchers at Boston University School of Medicine and Boston Medical Center have found that the majority of patients misusing drugs and alcohol have chronic pain and many are using these substances to "self-medicate" their pain.

According to the researchers, many illegal drugs such as marijuana and heroin have pain-relieving properties. The researchers screened approximately 25,000 patients in primary care for illegal drug use and misuse of prescription medications. Among these patients, 589 who screened positive for substance use were asked questions about chronic pain and their substance use. Substance use was defined as use of illegal drugs (heroin, marijuana, cocaine, etc.), use of prescription drugs in ways other than prescribed or high risk alcohol use.

They found that 87 percent of those who screened positive for illegal drug use, misuse of prescription drugs or heavy alcohol use suffered from chronic pain. Half of these patients graded the pain as severe. In the subgroup that was using illegal drugs, 51 percent reported using one or more drug specifically to alleviate physical pain. In those using prescription drugs without a prescription or using more than prescribed, 81 percent identified self-medication of pain as the reason for misuse. With regard to high risk alcohol use, the majority (79 percent) did so to manage pain.

"While the association between chronic pain and drug addiction has been observed in prior studies, this study goes one step further to quantify how many of these patients are using these substances specifically to treat chronic pain. It also measures the prevalence of chronic pain in patients who screen positive for illegal drug use and prescription drug abuse," explained corresponding author Daniel Alford, MD, MPH, associate professor of medicine and assistant dean of Continuing Medical Education and director of the Safe and Competent Opioid Prescribing Education (SCOPE of Pain) program at BUSM. He is also the director of BMC's Clinical Addiction Research and Education Unit.

Addiction Community Resources Toolkit

PDF....
http://goo.gl/zSwTdM

The Bipartisan Task Force to Combat the Heroin Epidemic has developed this toolkit in conjunction with the Addiction Policy Forum to connect families impacted by addiction with evidence­based resources around prevention, treatment, and recovery. Information for Caseworkers. 

This Toolkit includes resources around prevention, drug treatment, recovery support and general information for families, community organizations, schools, and parents concerned about addiction and looking for support. This toolkit was assembled to provide each Member of Congress and their staff resources to connect our constituents directly with resources. 

Please disseminate to your district office, make available on your website, and provide these useful resources to your constituents. Our hope is that during Opioid Awareness week we can not only work on meaningful legislation, but also help provide better support to the families in our communities struggling with this epidemic. 

Resources on Prevention, Treatment, and Recovery 

PREVENTION 
1. The Parent Toolkit ­ Whether your child is toddling through preschool, meandering through middle school or cruising through his ’20s ­­ here are tips to help guide him toward a healthy life at every age! 
2. Join a Community Anti­Drug Coalition ­ Community Anti­Drug Coalitions of America (CADCA) is the leading substance abuse prevention organization, representing over 5,000 community­based coalitions across the United States and in 22 countries who


Anxiety and Mental Health Accessibility

https://goo.gl/BssFPv

I saw a notice for a table at a local library branch. For two hours, a local “behavioral health” (that phrase is so creepy) organization would have a table available for people, “to learn more or to get information about ALL services [agency] offers.”

That sounded promising, so I went.

The entrance to the library was a sensory nightmare. I had to get past a food box hand-out at the door. I am glad someone was feeding people, but it made for a confusing sensory nightmare plus a big audience of strangers watching me trying to get information about a sensitive topic.

Inside, I struggled to make visual sense of the room. There was a table with a person at it, but no sign identifying who they were or why they were there. It used up just about my last drop of processing to get to the table.

So there I was, fidgeting, rocking, avoiding eye contact, having a really hard time of it and pretty sure it showed. “Is this the [agency] table?”

“Yes.” And they waited for me to say more.

“It said you would have information about your services?”

“What service do you need?”

Now … some of you are Autistic and some of you are parents to Autistics (and some of you are both.) So you know what I’m about to say.

I couldn’t make the words. And even if I could, I was not comfortable telling my troubles to a stranger in a very public setting.

I see now, at least somewhat, what they meant and what I was supposed to say, but in the moment, it was too much.

“What do you have?”

They rattled off a string of words faster than I could process them all– who knows? There might have been a better fit in there for me, but I managed to latch on to “mental health services.”

“Those. Mental health.”

They picked up a pamphlet, “you can call this number, and…”

“I don’t do phone,” I blurted. This should really be an expected response from someone with anxiety issues, right?

“Is there just a pamphlet I could read or something?” By now, I was hitting the end of my “spoons.”

They tried to hand me the same pamphlet. I looked at it. It was for alcoholics and addicts.

“I’m not an alcoholic,” I said, feeling lost and helpless and pretty certain the wizard had nothing in his black bag for me.

“Yes, but this phone number …”

I was sunk. It was back to the phone call. If I could have made a phone call, I would have done it already, not come to a table hoping to get information and answers about how [agency] might help me.

“Thank you,” and I took off out the door, double time, to go sit in my van where I shook and cried, getting myself together enough to drive away.


Come to think of it or not: Study shows how memories can be intentionally forgotten

http://goo.gl/q4TXoq

Context plays a big role in our memories, both good and bad. Bruce Springsteen's "Born to Run" on the car radio, for example, may remind you of your first love -- or your first speeding ticket. But a Dartmouth- and Princeton-led brain scanning study shows that people can intentionally forget past experiences by changing how they think about the context of those memories.

"Our hope was the scene images would bias the background, or contextual, thoughts that people had as they studied the words to include scene-related thoughts," says lead author Jeremy Manning, an assistant professor of psychological and brain sciences at Dartmouth. "We used fMRI to track how much people were thinking of scene-related things at each moment during our experiment. That allowed us to track, on a moment-by-moment basis, how those scene or context representations faded in and out of people's thoughts over time."

The study's participants were told to either forget or remember the random words presented to them interspersed between scene images. Right after they were told to forget, the fMRI showed that they "flushed out" the scene-related activity from their brains.

"It's like intentionally pushing thoughts of your grandmother's cooking out of your mind if you don't want to think about your grandmother at that moment," Manning says. "We were able to physically measure and quantify that process using brain data."

But when the researchers told participants to remember the studied list rather than forget it, this flushing out of scene-related thoughts didn't occur. Further, the amount that people flushed out scene-related thoughts predicted how many of the studied words they would later remember, which shows the process is effective at facilitating forgetting.

The study has two important implications. "First, memory studies are often concerned with how we remember rather than how we forget, and forgetting is typically viewed as a 'failure' in some sense, but sometimes forgetting can be beneficial, too," Manning says. "For example, we might want to forget a traumatic event, such as soldiers with PTSD. Or we might want to get old information 'out of our head,' so we can focus on learning new material. Our study identified one mechanism that supports these processes."


TRAUMA MAKES YOU LIVE IN 'BACKWARDS WORLD.'

http://goo.gl/L43Ctg

Trauma creates a backwards world. Especially repeated trauma. In trauma the ordinary and the extraordinary change places. What seems mundane becomes the warning sign of impending danger. What is dangerous becomes normal. What seems small becomes big, what is big, seems small. If you spend years with this backwards view of the world it can become habit.

This backwards view of the world—mundane is dangerous, dangerous is safe. Small is big, big is small. This backwards view is one of the invisible wounds of trauma. It isn’t listed anywhere on a symptom checklist. There are no medications to change your thinking. But this backwards view impacts your life, your decisions, your work, your relationships.

Being in a plane like my great uncle and getting immediate feedback that everything you know is backwards is a massive wake up call—you know immediately that you are looking at the situation from a vantage point that will impact your life. But when you have lived with the view that the mundane will kill you, but danger is safe long enough you don’t even notice that you are living on the other side of the looking glass. Your backwards world is the way the world is—at least for you.

The only way to see it is to break one of the backwards rules—do the opposite, check to see if your assumption is true.