The Mysterious Interior World of Exercise

https://goo.gl/pkU47z

When we exercise, far-flung parts of our bodies apparently communicate with one another, thanks to tiny, particle-filled balloons that move purposefully through the bloodstream from one cell to another, carrying pressing biochemical messages, according to an important new study of the biology of exercise.

The study helps to clarify some of the body-wide health effects of working out and also underscores just how physiologically complex exercise is.

For some time, scientists have suspected that the body’s internal organs are as gossipy and socially entangled as any 8th-grade classroom. It is thought that, under the right conditions, fat cells chat with muscle cells, and muscle cells whisper to brain cells and everybody seems to want to be buddies with the liver.

These interactions are especially abundant during exercise, when continued movement demands intricate coordination of many different systems within the body, including those that create cellular energy.

But the precise mechanics of how different parts of the body communicate during exercise (or at other times) have remained surprisingly mysterious. Scientists have shown that many tissues pump out hormones, such as insulin, and other proteins that move through the blood and jump-start physiological processes elsewhere in the body.


The Wrong Way to Treat Opioid Addiction

https://goo.gl/5xyYGP

Before Joe Thompson switched treatments for his opioid addiction, he was a devoted stay-at-home father, caring for his infant son after his wife returned to work. His recovery was aided by the anticraving medication buprenorphine. But after over two years free of heroin, Mr. Thompson, a former United Parcel Service worker from Iowa, relapsed and decided to try another kind of treatment program.

Unfortunately, his new counselors insisted that continuing his buprenorphine, though it was approved by the Food and Drug Administration, was just as bad as using heroin, according to his wife, Deborah. He wasn’t even allowed to start therapy until he’d been abstinent for several weeks. Stressed by withdrawal, he went to a third center. It, too, banned medication. Within a week of entering the program, he was dead from a heroin overdose. He was 35.

Buprenorphine is one of only two treatments proven to cut the death rate from opioid addiction by half or more. But the programs Mr. Thompson tried viewed abstinence as the only true recovery — even though abstinence treatment has not been shown to reduce mortality and is less effective than medication at preventing relapse.

Unfortunately, Mr. Thompson’s experience is more the rule than the exception. Only about one-third of American addiction programs offer what many experts worldwide see as the standard of care — long-term use of either methadone or buprenorphine. Most programs view medication as a crutch for short-term use and provide only talk therapies.


US Life Expectancy Declines Two Years in a Row

https://goo.gl/7YWij7

“It’s even worse than it looks,” Keith Humphreys, an addiction specialist at Stanford University, told The Washington PostEvidence suggests that studies could be underestimating opioid deaths by 20 percent or more, as reported in the American Journal of Preventive Medicine.

“Even if you ignored deaths from all other drugs, the opioid epidemic alone is deadlier than the AIDS epidemic at its peak,” Humphreys said.

In addition to higher numbers of opioid-related deaths, deaths from eight of the top ten leading causes of death in the U.S. also increased in 2016 contributing to the lifespan decline. The mortality rate from stroke and heart disease, the two leading causes of death in the United States, increased in 2016 after steadily decreasing in recent years.

Scientists, physicians, experts and medical professionals realize these non-communicable diseases need to be addressed. In addition, the medical community must improve access and quality of care to create a healthier society. Income inequality, nutritional differences and lingering unemployment are also all major influences on the lifespan decline in the United States, experts say.


What's Next in Clinical TMS Study for PTSD, MDD

https://goo.gl/vtUCTW

In a recently-published commentary, researchers discussed the growing interest in transcranial magnetic stimulation (TMS) therapy for post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), and what it brings in patient symptoms.

TMS, which was approved by the US Food and Drugs Administration (FDA) for drug-resistant depression in 2009, has recently experienced a growth in clinical use, Mira Hammoud, MD, and Mohammed Milad, PhD, from the Department of Psychiatry, University of Illinois at Chicago, noted in their commentary.

Although previous studies have supported the use of TMS for treatment of PTSD, they haven’t clarified the mechanisms it uses to affect and improve symptoms. Use of TMS to treat MDD has a larger collection of literature that, according to the commentary, supports the idea that “TMS modulates functional connectivity in several brain regions implicated in the pathophysiology of MDD, including the subgenual anterior cingulate cortex (sgACC) and its connections with the default mode network (DMN).”

The current research has been related to treating MDD or PTSD individually with TMS, rather than treating the issues concurrently, which is common.

Their commentary was in response to a recent article in which a research team looked at “neural mechanisms of clinical response to TMS for comorbid PTSD and MDD” in an attempt to ascertain imaging predictors of symptom improvement following treatment with TMS, and to determine the network mechanisms of TMS.

The study much-needed insight into how TMS might “induce a clinical response in a cohort with comorbid MDD and PTSD,” Hammoud and Milad said. As a result, several brain regions commonly examined in the pathophysiology of MDD and PTSD, such as the insular cortex and amygdala, are implicated for their functional connectivity.


A 14-Year-Old Made An App To Help Alzheimer’s Patients Recognize Their Loved Ones

https://goo.gl/9D3Rjg

When Emma Yang was 7 or 8 years old, her grandmother became increasingly forgetful. Over the next few years, those memory problems, caused by early Alzheimer’s disease, worsened. Yang, who learned to code at an early age, decided to create an app to help.

“I have personal experience with how the disease can affect not only the patient, but also family and friends. When I was about 11 or 12, I got really interested in using technology for social good to help other people around the world,” says Yang, who is now 14.

In her app under development, called Timeless, Alzheimer’s patients can scroll through photos of friends and family, and the app will tell them who the person is and how they’re related to the patient using facial recognition tech. If a patient doesn’t recognize someone in the same room, they can take a picture and the tech will also try to automatically identify them.


Does Being Clean Require Abstinence?

I had a client with bipolar who died in the 1970's because he was put through a program that allowed no medications at all, even aspirin.
https://goo.gl/aXuCte

Megan knew her baby girl was going through withdrawal, because everything about her was tight. This was a feeling she recognized. “That’s what it’s like,” she explains. “You’re not yourself.” She holds up her fists to demonstrate. The baby wouldn’t stop crying. She couldn’t get comfortable. For almost the entire nine months of her pregnancy, Megan had been on buprenorphine (brand name Suboxone) to treat opioid dependency. Stephanie Bobby, the nurse in charge of the Pregnancy Recovery Center (PRC), warned Megan that withdrawal was a possibility. The chances were one in three, although Megan never thought it would happen to her child.

She was scared and didn’t want it to be true, but Megan knew she had to do what was best for her baby. The nurses at Magee Women’s Hospital in Pittsburgh, where the PRC is housed in the basement, treated her baby for withdrawal, or neonatal abstinence syndrome (NAS), for 17 days.

Megan, who talks quickly and seems capable of getting anything done, stayed on buprenorphine for the next two years. When she and her husband — also treated with buprenorphine for opioid addiction — started talking about having a second child, the thought of putting another baby through withdrawal was unbearable. Megan wouldn’t even consider getting pregnant until she’d slowly weaned herself off the buprenorphine.

When Bobby found out Megan was completely off buprenorphine, she asked her to interview for the peer navigator position the PRC was creating with grant money. As a peer navigator, she’d guide PRC patients using her firsthand experience with the recovery process. She knew what they’d be going through. The PRC maintains that medication-assisted treatment (MAT), such as buprenorphine, can be a long-term solution for addiction, and the hospital does not propagate abstinence, yet they wouldn’t hire Megan if she was still taking the medication.

This is a confusing contradiction that raises the question: Does being “clean” require abstinence?

There are two simple and contradictory answers.

One, yes. Twelve-step programs such as Alcoholics Anonymous and Narcotics Anonymous work on the basis of complete abstinence. For example, no marijuana in AA. They aren’t going to kick you out (because according to one of their traditions, “the only requirement for membership is the desire to stop drinking [using]”), but if you tell people you’re smoking marijuana, someone is probably going to tell you that you aren’t “sober.”

Two, no. Medication-assisted treatment is a treatment, just like AA and NA are programs of treatment. Buprenorphine brings you back to normal and takes the edge off without getting you high, Bobby says. For Megan, it was her safety net. It’s just like insulin for diabetics, Bobby and others insist. Diet and exercise help, but you don’t tell people they need to eventually get rid of the insulin and manage their disease with diet and exercise alone.


Workplace Bullying, Violence Tied to T2D Risk

https://goo.gl/uhq5FV

Bullying and violence in the workplace were linked with an increased risk for type 2 diabetes in a large Scandinavian cohort study.

Over approximately 12 years of follow-up, being bullied at work was associated with a 46% increase in risk for developing type 2 diabetes (hazard ratio 1.46, 95% CI 1.23-1.74), after adjusting for factors including age, sex, education level, and marital status, reported Tianwei Xu, a PhD fellow at the University of Copenhagen in Denmark, and colleagues.

Similarly, exposure to workplace violence or threats of violence was linked with a 26% rise in type 2 diabetes risk (HR 1.26, 95% CI 1.02-1.56), the authors wrote online in Diabetologia.

Approximately 9% of participants reported bullying at work, and 12% said they had experienced workplace violence. The exposure to violence varied greatly among different occupations. The highest prevalence of violence or threats of violence were found among occupations with frequent client contact, including social workers (46%), personal and protective service workers (29%), healthcare professionals (25%), and teachers (16%).

The depression and anxiety resulting from workplace bullying or violence might contribute to diabetes risk by chronic activation of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system, the authors said, adding that impaired sleep might also increase diabetes risk indirectly.


THE SECRET HISTORY OF FACEBOOK DEPRESSION

https://goo.gl/9LxKwR

Since it launched in 2004, Facebook has been working to “give people the power to share and make the world more open and connected.”

This sounds great. But is it, actually?

Does connecting with everyone you’ve ever met ever on Facebook make you happy? Does sharing everything with them on Facebook make you jump out of your seat with joy? Probably not.

In fact, if the research is any indication, you may actually be finding Facebook and other social media sites aren’t so great for your mental health. Instead of feeling blissfully open and connected with your friends, you feel inadequate or maybe even a bit depressed.

Is social media making us sad because technology is inherently alienating? Is Facebook actually just evil?

We’ve been asking questions about technology like this for a rather long time. But the answer is a bit more complicated.

The trouble it caused went like this.

In everyday life, we tend to have different sides of ourselves that come out in different contexts. For example, the way you are at work is probably different from the way you might be at a bar or at a church or temple.

Sociologist Erving Goffman used concepts of theatre to explain these different aspects of our identities, for example, front stage and back stage.

But on Facebook, all these stages or contexts were mashed together. The result was what internet researchers called context collapse. People were even getting fired when one aspect of their lives was discovered by another (i.e. their boss!).

YOUR PERFECT SELF

The key to understanding social media depression lies in the social norm that has emerged around how we manage Facebook’s context collapse in a way that is acceptable in all contexts. That social norm is being your perfect self. And the consequence of that is we are all performing our perfect selves, thus all making each other feel depressed and inadequate.

IT DIDN’T HAVE TO BE THIS WAY

Before Facebook, there were many other sites that did similar things but in a different way. My favourite was LiveJournal (which still exists in a different incarnation, but that’s a whole other story).


DDD: Living with Depersonalization Derealization Disorder

https://goo.gl/2c64UZ

First, a quick caveat: I am not a physician, nor counselor or psychologist, and this article deals with my personal experiences with DDD and finding treatment. Consult with your own doctor or care provider if you are in need of professional help.

If I had to pick the most impactful moment of my life thus far, developing Depersonalization-Derealization Disorder (DDD) would unfortunately be the first on my list. Having lived with the disorder for a bit over a year now, one of the most frustrating aspects of this disorder is the relative invisibility and lack of attention it has garnered thus far, both in the general public and in medical communities. It’s time to change this.

This article is meant to be an overview of DDD from a non-professional point of view. It’s intended both for people who think they may suffer from the disorder, and for people who want to expand their awareness about mental health in general. Half of the article (Defining DDD and Living with DDD) is directed at those suffering from dissociative disorders, and half (Describing DDD and Helping with DDD) is intended for a broader audience that want a better understanding of what it’s like to live with, and how to support others.

Go brew yourself a cup of tea (I’m sipping peppermint tea as I write this), because there are a lot of definitions and examples coming up. I promise it’s worth it in the long term.

Ready? Let’s go.


“THE MARINES AND TET”

My personal 50th-anniversary events in combat start in early March this year. I posted this also because of the effort the Newseum took to make the exhibit accessible.

https://goo.gl/pSQY1J

On the 50th anniversary of the Tet Offensive, “The Marines and Tet: The Battle That Changed the Vietnam War” will showcase the work of John Olson, a young photographer with Stars and Stripes who spent three days with the Marines at the 1968 Battle of Huêˊ (pronounced hway), the bloodiest single battle of the Vietnam War. Huêˊ was one of more than 100 cities and villages that North Vietnamese forces struck with a surprise attack on the holiday known as Tet.

This innovative exhibit will feature 20 large-format photographs and 10 tactile versions of those photographs with touch-activated sensors that provide audio interviews, allowing blind and low-vision visitors to experience the images through touch and sound. The Newseum is the first museum in the United States to host a major tactile exhibit designed to include blind and low-vision visitors.

Olson’s photographs were featured in Life magazine, and he won the Robert Capa Gold Medal for his work. His image of a tank carrying wounded Marines at the Battle of Huêˊ became one of the most iconic images of the Vietnam War.

The exhibit will also include unique artifacts, including Nikon cameras that Olson used in Vietnam and personal items from the Marines, as well as newspapers and magazines that published Olson’s photography. Ten Marines were interviewed for the exhibit, including the battalion and company commanders, some of them revealing their stories publicly for the first time.

Some of the Marines in Olson’s photographs have been identified, but others remain nameless. As part of his mission to identify all the men in the photos, Olson has set up www.tet1968.com, a website that allows the public to assist with his research and share their stories of Tet.