Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort

Gabapentin best-known brand is Neurontin, but the article includes the names of other brands.....

https://goo.gl/W3yEYi

Key Points

Question  What is the effect of perioperative gabapentin on remote pain resolution and opioid cessation after surgery?

Findings  In this randomized clinical trial of 422 patients undergoing a variety of operations, no significant difference was found in time to pain cessation between patients receiving 72 hours of perioperative gabapentin compared with placebo. However, perioperative gabapentin had a significant effect on promoting opioid cessation after surgery.

Meaning  Seventy-two hours of perioperative gabapentin use may promote opioid cessation after surgery and decrease the duration of postoperative opioid use.

SAMHSA-HRSA Center for Integrated Health Solutions: Intimate Partner Violence

https://goo.gl/Ki3DzB

This webpage, focused on Intimate Partner Violence (IPV), is geared towards health, behavioral health and integrated care leadership, providers, and patients/consumers. The information and resources listed here can be easily adapted to other groups and settings.

It is vital for all staff employed by health, behavioral health, and integrated care organizations to understand the nature and impact of trauma and how to use principles and practices that can promote recovery and healing: Trauma-Informed Approaches. In addition to information and resources on IPV, this page provides links to resources on Trauma and Trauma-Informed Approaches, as well as Suicide Prevention, that we encourage you to explore.

According to the Centers for Disease Control and Prevention (CDC), IPV is a serious, preventable public health problem. The CDC defines Intimate Partner Violence (also described as domestic violence [DV]) as "physical, sexual, or psychological harm by a current or former partner or spouse. This type of violence can occur among heterosexual or same-sex couples and does not require sexual intimacy."

The CDC reports that IPV is highly prevalent and preventable. IPV affects millions of people in the U.S. each year. Data from the 2010-2012 National Intimate Partner and Sexual Violence Survey (NISVS) indicate that nearly one in four adult women (23 percent) and approximately one in nine men (11 percent) in the U.S. report having experienced severe physical violence (e.g., being kicked, beaten, choked, or burned on purpose; having a weapon used against them; etc.) from an intimate partner in their lifetime. Additionally, one in three women and one in six men have experienced contact sexual violence (this includes rape, being made to penetrate someone else, sexual coercion, and/or unwanted sexual contact) from an intimate partner. One in six women and one in 19 men in the U.S. report having been stalked by an intimate partner, and nearly half of all women (47 percent) and men (47 percent) have experienced psychological aggression, such as humiliating or controlling behaviors.

Having experienced other forms of trauma or violence, such as child sexual or physical abuse or exposure to parental or caregiver IPV, is an important risk factor for perpetrating and experiencing IPV. IPV is also linked to increased risk for suicide in both boys and girls who experience teen dating violence (TDV) and for women exposed to partner violence. These women are nearly five times more likely to attempt suicide as women not exposed to partner violence. IPV is also a precipitating factor for suicide among men. (Reference: NISVS)

Health consequences are significant and important for behavioral, health, and integrated care providers to be aware of. Approximately 41 percent of female IPV survivors and 14 percent of male IPV survivors experience some form of physical injury that may also result in death. Data from U.S. crime reports suggest about one in six murder victims and more than 40 percent of female homicide victims in the U.S. are killed by an intimate partner. (Reference: NISVS)

SAMHSA-HRSA Center for Integrated Health Solutions: Suicide Prevention

https://goo.gl/we5DEX

This webpage, focused on suicide and suicide prevention, is geared toward health, behavioral health, and integrated care leadership, providers, and patients/consumers. The information and resources listed here can be easily adapted to other groups and settings. Suicide, Intimate Partner Violence (IPV), and Trauma are often interrelated. Trauma is highly prevalent and a major risk factor for suicide and IPV.  It is, therefore, vital for all staff employed by health, behavioral health, and integrated care organizations to understand the nature and impact of trauma and how to use principles and practices that can promote recovery and healing: Trauma-Informed Approaches. In addition to information and resources on Suicide Prevention, at the CIHS website you will find links to Trauma and Trauma-Informed Approaches webpages, as well as IPV webpages, which we encourage you to explore.

Every 12 minutes, someone in the U.S. takes his or her own life. And for every one suicide, there are 25 attempts. Suicide is the 10th leading cause of death in the U.S., and the number and rate of suicides are rising. Each year, more than 900,000 emergency department (ED) visits are made by people thinking of suicide.

Suicide as a public health issue affects everyone: families, health care providers, school personnel, faith communities, friends, and government. The good news is that suicide is often preventable. Research findings by the Henry Ford Health System clearly make the case that health care providers can play a critically important role in preventing suicides by identifying those at risk and responding appropriately. They found that the mental health conditions of most people who die by suicide remain undiagnosed, even though most visit a primary care provider, ED, or medical specialist within the year before they die. The risk of suicide attempts and death is highest within the first 30 days after a person is discharged from an ED or inpatient psychiatric unit, yet as many as 70 percent of patients of all ages who attempt suicide never attend their first outpatient appointment. Therefore, access to clinical interventions and continuity of care after discharge is critical for preventing suicide.


SAMHSA-HRSA Center for Integrated Health Solutions: Trauma

https://goo.gl/qeZwoU

This webpage, focused on trauma and trauma-informed approaches, is geared towards health, behavioral health and integrated care leadership, staff, and patients/consumers. The information and resources listed here can be easily adapted to other groups and settings such as schools. Three important areas of health: trauma, Intimate Partner Violence (IPV), and suicide are interrelated as trauma is a major risk factor for IPV and suicide.  It is vital for all leadership and staff of health, behavioral health, and integrated care organizations to understand the nature and impact of trauma and how to use principles and practices that can promote recovery and healing: Trauma-Informed Approaches. In addition to information and resources on Trauma and Trauma-Informed Approaches, you will find links to IPV as well as Suicide Prevention webpages that we encourage you to explore.

Trauma is highly prevalent, can impact a person at any time during their lifespan and may present as mental health, substance use or physical health conditions.

Since trauma can have serious effects on health, behaviors, relationships, work, school, and other aspects of life, it is important for behavioral health, health care, and other providers to gain the knowledge and skills needed to promote healing, recovery, and wellness. A Trauma-Informed Approach, often referred to as trauma-informed care (TIC), is a promising model for organizational change in health, behavioral, health, and other settings that promotes resilience in staff and patients. Key principles of this approach include organizational safety, trustworthiness, transparency, cultural sensitivity, collaboration, and empowerment among and between staff and patients. This approach recognizes the role trauma plays in the lives of patients/consumers and seeks to shift the clinical perspective from “what’s wrong with you” to “what happened to you” by recognizing and accepting symptoms and difficult behaviors as strategies developed to cope with childhood trauma.


Psych Disorders Often Come Before Youth SLE Diagnosis

https://goo.gl/CvXJTs

Psychiatric disorders often preceded a diagnosis of systemic lupus erythematosus (SLE) in young people, and were strongly associated with heavy use of healthcare services in the prediagnosis year for nonpsychiatric problems suggestive of underlying SLE, researchers reported.

Compared with matched healthy controls, youth with SLE had significantly more hospital visits in the year before diagnosis across all clinical settings, according to Joyce C. Chang, MD, of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, and colleagues:

  1. Ambulatory: incidence rate ratio 2.48 (P<0.001)
  2. Emergency department (ED): IRR 3.42 (P<0.001)
  3. Inpatient: IRR 3.02 (P<0.001)

Chang's group noted that autoantibodies and clinical symptoms can precede SLE diagnosis by years, but not enough to allow definitive diagnosis early in the disease course. They said exploring patterns of prediagnosis healthcare use is a first step in characterizing the path from symptom onset to diagnosis, and may provide insight into strategies to expedite SLE diagnosis and treatment.

"Examining variable diagnostic trajectories of youth presenting for acute care preceding SLE diagnosis, and increased attention to psychiatric morbidity may help improve care for youth with new-onset SLE," they wrote.



Stuttering: Stop Signals in the Brain Disturb Speech Flow

The first time I heard the theory that activity in the right (non-language) hemisphere was interfering with the smooth flow of speech in the left (language) hemisphere was in the early 1970's. Interesting to see it proved out almost 5 decades later. Also, in general, one of the jobs of the right hemisphere is to reduce activity in both hemispheres, so this fits in as well.....

https://goo.gl/LrV8D5

Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig and at the University Medical Center Göttingen have now gained crucial insights: The hyperactivity in regions of the right hemisphere seems to be central for stuttering: “Parts of the right inferior frontal gyrus (IFG) are particularly active when we stop actions, such as hand or speech movements”, says Nicole Neef, neuroscientist at MPI CBS and first author of the new study. “If this region is overactive, it hinders other brain areas that are involved in the initiation and termination of movements. In people who stutter, the brain regions that are responsible for speech movements are particularly affected.”

What It’s Really Like To Live With Severe Migraines

https://goo.gl/6EMQkT

The migraines I thought I’d left behind in my teens are back with a vengeance in my 50s.

m not alone. Migraines affect more than 38 million people in the United States, resulting in 113 million lost workdays a year, costing American employers $13 billion annually. The World Health Organization classifies it as the most disabling neurologic disease on the planet and it’s even worse for women. A study from the Women’s Health Initiative found that three times more women experience migraines than men.

Migraines affect more than 38 million Americans, resulting in 113 million lost workdays a year.

Many of the symptoms I experience are common to other sufferers. According to migraine expert Elizabeth Seng, Ph.D., research assistant professor at Einstein College of Medicine’s Saul R. Korey Department of Neurology, the pain of a migraine is usually pulsing or pounding and one-sided. It becomes worse when people try to engage in normal activities. Nausea and vomiting is typical, as is sensitivity to light and sound and visual disturbances, like seeing dark spots in your field of vision.

There are warning signs migraine sufferers may experience a couple of minutes to a couple of hours before the actual pain begins. “People might have difficulty concentrating or difficulty finding words,” Seng told me. “Sometimes people will start yawning or have diarrhea or constipation. Some of my patients have described sudden feelings of depression or suddenly getting irritable or feeling hyperactive — all of those could potentially be warning signs of migraine, and you want to be able to catch it before it starts. This why it’s such a challenge for people who are in the workplace to manage migraine. Because we’re busy focusing on what we’re doing and it can be difficult to notice these warning signs when they’re coming on.”


Study Examines the Difficulty of Withdrawing from Antidepressant Drugs

https://goo.gl/F6UiZU

Researchers in the Netherlands, led by Dr. Rhona Eveleigh, investigated a tailored approach to withdrawing from longterm antidepressants prescribed inconsistently with clinical guidelines. Their results suggest that antidepressants are overprescribed and that once they are started it is difficult to discontinue their use.

“This study concludes that overtreatment with antidepressants is very prevalent and that a considerable proportion of long-term use has no clinical justification,” the authors write. “As such, this study aims to reduce inappropriate long-term antidepressant use in general practice.”

Research has demonstrated that antidepressant drugs are not significantly superior to placebo at reducing depressive symptoms except in cases of severe depression. However, clinical practice has failed to reflect this research and antidepressants continue to be prescribed as a first-line treatment for mild to moderate depression. The question of how to withdraw from antidepressants when they have been prescribed inappropriately has become central to remediating overtreatment.

The researchers evaluate the effectiveness of a recommendation to cease treatment with antidepressants by implementing an approach tailored to the patient and the psychiatric diagnosis. The aim of this study is driven by the high levels of problematic long-term antidepressant use, classified as “overtreatment.”

This usage is contraindicated explicitly by research recommending the limited duration of antidepressant use. Moreover, the authors write that the effectiveness of antidepressants is “questionable,” with five out of every six users failing to experience benefits. They explain:

“It is important to discuss how patients can use their own resources to cope with their problems; providing medication might be counterproductive, as medication use may disincentivize a patient to find non-pharmacological solutions, thereby diminishing patient empowerment in a context where regaining control is essential for recovery.”


If it is absurd, then why do you do it? The richer the obsessional experience, the more compelling the compulsion

https://goo.gl/zho9u2

Mounting evidence suggests that obsessive intrusions are often accompanied and amplified by perceptual experiences of different modalities (e.g., feeling dirt on one's skin while experiencing intrusive thoughts about contamination). 

Pilot studies conducted online with individuals endorsing mild obsessive–compulsive symptoms have linked the co-occurrence of perceptual experiences and obsessions to the severity of subsequent compulsive behaviour as well as low insight. However, it is presently unclear whether sensory experiences accompany all types of obsessional thoughts or are restricted to certain preoccupations (e.g., contamination and aggression). 

The present study examined a clinical inpatient and outpatient sample with a formally diagnosed obsessive–compulsive disorder (N = 34). Perceptual properties of intrusive thoughts were assessed with the Sensory Properties of Obsessions Questionnaire. The prevalence of perception-laden obsessive thoughts was comparable with prior studies (73.5%), but the intensity was significantly greater. 

No association was observed between perceptual experiences and expert-rated insight. However, the severity of perception-laden obsessions predicted the frequency of and impairment associated with compulsive behaviour. This was particularly strong for obsessions about contamination. The present study confirms the high prevalence and clinical relevance of perceptual experiences that accompany obsessions and further challenges the traditional trichotomy splitting mental phenomena into thoughts, intrusions, and hallucinations.


Schizophrenia May Not Be As Deeply Rooted As Thought

https://goo.gl/ZomzUG

“There’s a lot of effort in the schizophrenia field to help people through what’s called cognitive remediation, which is basically a bottom-up process of learning, memory and attention,” Grant said. “But we think that having interventions that target positive and negative beliefs, along with goals, would be key in terms of helping the individuals have better lives, the lives that they want.” One intervention is called recovery-oriented cognitive therapy (CT-R), a hands-on, active approach that focuses on life aspirations, successful goal achievement, development of resiliency in the face of stressful symptoms and life events, all to promote positive beliefs and neutralize negative attitudes. CT-R was created by Grant, along with Aaron T. Beck, MD, an emeritus professor in the department of Psychiatry at Penn, and co-author on the study.

A June 2017 study in the journal Psychiatric Services, authored by this same team, found that CT-R is effective in individuals with schizophrenia who are functioning poorly. The study was a follow up to a randomized clinical trail and showed that participants who received CT-R for 18 months, as compared to those who received standard treatment (e.g., anti-psychotic medications, case management), showed major improvements in daily functioning, motivation and psychotic symptoms that endured after the therapy was completed. Importantly, those with the longest course of illness showed improvement by the end of the study.